Interferon hepatitis b

Phases of Chronic Hepatitis B. Pegylated interferon -α (PEG-IFN-α) is a first line option in the treatment of chronic hepatitis B. Compared with nucleos(t)ide analogues (NAs), therapy with PEG-IFN-α has the advantages of finite treatment duration and higher rates. How does interferon treat chronic hepatitis B ? Treating Hepatitis With Interferon. It can prevent serious liver damage, but it also has many side effects, some of them.

Interferon is a powerful drug used to treat hepatitis types B , C, and D. Both hepatitis B and hepatitis C are treated with IFN-α , often in combination with other antiviral drugs. Some of those treated with interferon have a sustained virological response and can eliminate hepatitis virus. Objectifs du traitement des hépatites B chroniques.

Compte tenu des données de l’histoire naturelle des hépatites B chroniques, les objectifs du traitement antiviral sont de contrôler la réplication virale, afin d’améliorer la maladie hépatique et d’empêcher la progression de celle-ci vers les complications (cirrhose et carcinome hépatocellulaire). By contrast, the risk of developing chronic hepatitis B infection is only 3– among those who are exposed to the infection as adults. Although chronic hepatitis B infection acquired later in life can result in cirrhosis and liver failure, whether these patients face an increased risk of hepatocellular carcinoma is not clear. Chronic hepatitis B virus (HBV) infection imposes a severe burden on global public health. Charles Weissmann at the University of Zurich.

An estimated one third of the global population has been infected with the hepatitis B virus (HBV). When sick with the flu, the body makes extra interferon to defeat the virus causing the illness. The extra interferon causes symptoms such as fever, nausea, achy and sore muscles, joint pain and fatigue.

This is called an antiviral effect. Die akute Hepatitis B muss aufgrund der hohen Spontanheilungsrate (95–) in der Regel nicht behandelt werden. Eine Ausnahme stellen Personen mit besonders schwerer akuter Hepatitis B dar.

Nach Abklingen der akuten Leberentzündung innerhalb von vier bis sechs Wochen ist in der Regel mit einem Ausheilen der Hepatitis B zu rechnen. Les symptômes de la maladie aiguë sont essentiellement une inflammation du foie, avec ou sans ictère et des troubles digestifs avec nausées et vomissements. For chronic active hepatitis B ALT levels may remain constant or decrease over the course of treatment however if ALT flares to = time base level then treatment with Intron-A should be continued unless signs or symptoms of liver failure are observed. Cooksley, M explores the place that interferon currently holds in the therapeutic armamentarium against hepatitis B. Through a systematic review. Both conventional interferon and pegylated interferon are approved in the United States.

See Standard and pegylated interferon for chronic hepatitis B virus infection. Patients received a 6-month course of alpha- interferon 2a, MU subcutaneously three times per week. The mean follow-up after treatment was months.

The interferon -induced flare of hepatitis may be severe and is particularly dangerous in patients with advanced liver disease and cirrhosis, who may not be able to tolerate a flare of hepatitis. For this reason, interferon therapy is relatively contraindicated in patients with cirrhosis caused by chronic hepatitis B infection. A slow release form of interferon , pegylated interferon (also known as peginterferon), is given as a shot once a week. Peginterferon is used more often than interferon to treat hepatitis B. Treatment with interferons can last months to year. Hepatitis B reactivation has also been noted on those on immunosuppresive drugs, although this is very rare in patients who have lost the surface antigen.

Several factors have been identified that can improve or reduce the chances of a successful response but there is as yet no way to identify individuals who will respond. Lorsque le virus de l’hépatite B est très actif ou lorsque le foie montre des signes d’inflammation ou de fibrose, le médecin envisage le recours aux traitements contre le virus de l’hépatite B. Dans les formes graves d’hépatite B chronique, et en particulier chez les personnes où elle est diagnostiquée très tar une.